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مطالعات in vitro
Finally, the mechanisms of action behind the therapeutic efficacy of ixmyelocel-T remain to be identified, although results from a rat hindlimb ischemia model and in vitro studies suggest that the cells in ixmyelocel-T promote angiogenesis [59].
In Vivo Macrophages • Do the phenotypes that are defined based on in vitro studies translate into
So, in addition to the existence of several monocyte phenotypes, each possesses varying potentials to differentiate into different macrophage phenotypes as shown through these in vitro studies.
The group also performed in vitro studies to determine the molecular interaction between MSCs and macrophages that leads to IL-10 upregulation.
Through in vitro studies, Faulknor et al
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